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Ampersand Biomedicines enables a new way of programming medicines that work precisely where needed in the body and nowhere else. The company’s computationally powered Address, Navigate, Determine (AND)™ Platform identifies ideal addresses for drug localization and informs the design of AND-Body™ Therapeutics that have the optimal therapeutic effect. AND-Body therapeutics combine a localizing element that enables disease-specific precision with an actuator specifically chosen for disease modification. The localizer’s primary function is to anchor these medicines in the diseased tissue. The actuator is responsible for inducing the desired therapeutic effect. This approach enables improved target engagement while sparing on-target, off-tissue side effects.